Báo cáo hóa học: " Could FIV zoonosis responsible of the breakdown of the pathocenosis which has reduced the European CCR5-Delta32 allele frequencies?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Could FIV zoonosis responsible of the breakdown of the pathocenosis which has reduced the European CCR5-Delta32 allele frequencies? | Virology Journal BioMed Central Research Could FIV zoonosis responsible of the breakdown of the pathocenosis which has reduced the European CCR5-Delta32 allele frequencies Eric Faure Address LATP CNRS-UMR 6632 IFR48 Infectiopole Evolution biologique et modélisation case 5 Université de Provence Place Victor Hugo 13331 Marseille cedex 3 France Email Eric Faure - Open Access Published 16 October 2008 Virology Journal 2008 5 119 doi l743-422X-5-ll 9 Received 26 August 2008 Accepted l6 October 2008 This article is available from http content 5 l l 19 2008 Faure licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In Europe the north-south downhill cline frequency of the chemokine receptor CCR5 allele with a 32-bp deletion CCR5-A32 raises interesting questions for evolutionary biologists. We had suggested first that in the past the European colonizers principally Romans might have been instrumental of a progressively decrease of the frequencies southwards. Indeed statistical analyses suggested strong negative correlations between the allele frequency and historical parameters including the colonization dates by Mediterranean civilisations. The gene flows from colonizers to native populations were extremely low but colonizers are responsible of the spread of several diseases suggesting that the dissemination of parasites in naive populations could have induced a breakdown rupture of the fragile pathocenosis changing the balance among diseases. The new equilibrium state has been reached through a negative selection of the null allele. Results Most of the human diseases are .