Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Immune response during acute Chandipura viral infection in experimentally infected susceptible mice | BioMed Central Virology Journal Research Immune response during acute Chandipura viral infection in experimentally infected susceptible mice Anukumar Balakrishnan 1 and Akhilash Chandra Mishra2 Address 1Chandipura virus group National Institute of Virology 20-A Dr. Ambedkar Road Post Box-11 Pune-411001 Maharashtra India and 2Director National Institute of Virology 20-A Dr. Ambedkar Road Post Box-11 Pune-411001 Maharashtra India Email Anukumar Balakrishnan - anukumar_b74@ Akhilash Chandra Mishra - acm1750@ Corresponding author Open Access Published 20 October 2008 Received 2 September 2008 Accepted 20 October 2008 Virology Journal 2008 5 121 doi 1743-422X-5-121 This article is available from http content 5 1 121 2008 Balakrishnan and Mishra licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Age dependent susceptibility was observed in Chandipura virus CHPV infected mice through intravenous and intraperitoneal route. Adult mice were susceptible only through intracerebral route of infection. Immature neuron and some other biological variables including immature immune system are considered to be important factor for age related susceptibility in some diseases. As Chandipura virus infects both young and adult mice brain through intracerebral route the role of immune system during peripheral infection in young susceptible mice needs to be studied. Results Through intravenous route of infection the virus produces vireamia and cross the blood brain barrier BBB to replicate in the central nervous system. Circulating virus is effectively cleared by virus specific IgM antibody but .
