Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine | Virology Journal BioMed Central Open Access Research Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine Corey J Crevar1 and Ted M Ross 1 2 Address 1Center for Vaccine Research University of Pittsburgh Pittsburgh PA USA and 2Department of Microbiology and Molecular Genetics University of Pittsburgh Pittsburgh PA USA Email Corey J Crevar - cjc63@ Ted M Ross - tmr15@ Corresponding author Published 28 October 2008 Received 17 August 2008 Accepted 28 October 2008 Virology journal 2008 5 131 doi l743-422X-5-l3l This article is available from http content 5 l l3l 2008 Crevar and Ross licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Currently licensed human vaccines are subtype-specific and do not protect against pandemic H5Nl viruses. Previously our group has reported on the construction of an influenza virus-like particle VLP as a new generation candidate vaccine. A mixture of influenza H5Nl VLPs representing clade l and 2 viruses were examined for the ability to elicit protective immunity against isolates from various clades and subclades of H5Nl. Results Mice were vaccinated intramuscularly with each VLP individually the mixture of VLPs a mixture of purified recombinant hemagglutinin rHA or mock vaccinated. Elicited antibodies were assayed for the hemagglutination-inhibition HAI activity against clades l and clade 2 isolates. Mice vaccinated with each VLP individually or in a mixture had robust HAI responses against homologous viruses and HAI responses against the clade virus Anh 05. However these vaccines did not induce an HAI response against the clade
