Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Quantitative profiling of housekeeping and Epstein-Barr virus gene transcription in Burkitt lymphoma cell lines using an oligonucleotide microarray | Virology Journal BioMed Central Open Access Methodology Quantitative profiling of housekeeping and Epstein-Barr virus gene transcription in Burkitt lymphoma cell lines using an oligonucleotide microarray Michele Bernasconi1 Christoph Berger1 Jurg A Sigrist1 Athos Bonanomi1 Jens Sobek2 Felix K Niggli1 and David Nadal 1 Address Division of Infectious Diseases and Division of Oncology University Children s Hospital of Zurich August Forel-Strasse 1 CH-8008 Zurich Switzerland and functional Genomics Center of the University of Zurich Winterthurerstrasse 190CH-8057 Zurich Switzerland Email Michele Bernasconi - Christoph Berger - Jurg A Sigrist - Athos Bonanomi - Jens Sobek - Felix KNiggli - David Nadal - Corresponding author Published 06 June 2006 Received 02 February 2006 Accepted 06 June 2006 Virology journal 2006 3 43 doi 186 1743-422X-3-43 This article is available from http content 3 1 43 2006 Bernasconi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background The Epstein-Barr virus EBV is associated with lymphoid malignancies including Burkitt s lymphoma BL and can transform human B cells in vitro. EBV-harboring cell lines are widely used to investigate lymphocyte transformation and oncogenesis. Qualitative EBV gene expression has been extensively described but knowledge of quantitative transcription is lacking. We hypothesized that transcription levels of EBNAI the gene essential for EBV persistence .
