Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Discovery of significant variants containing large deletions in the 5'UTR of human hepatitis C virus (HCV) | Virology Journal BioMed Central Research Discovery of significant variants containing large deletions in the 5 UTR of human hepatitis C virus HCV Dennis Revie1 Michael O Alberti1 Ravi S Braich2 4 David Bayles2 John G Prichard3 and S Zaki Salahuddin 2 Open Access Address Department of Biology California Lutheran University Thousand Oaks California USA 2California Institute of Molecular Medicine Ventura California USA 3Ventura County Medical Center Ventura California USA and 4Alnylam Pharmaceuticals Cambridge Massachusetts USA Email Dennis Revie - revie@ Michael O Alberti - moalberti@ Ravi S Braich - rsbraich@ David Bayles - dave@ John G Prichard - johnprichard@ S Zaki Salahuddin - phoenix@ Corresponding author Published 29 September 2006 Virology Journal 2006 3 82 doi 1743-422X-3-82 Received 08 September 2006 Accepted 29 September 2006 This article is available from http content 3 1 82 2006 Revie et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ We recently reported the isolation and in vitro replication of hepatitis C virus. These isolates were termed CIMM-HCV and analyzed to establish genotypes and subtypes which are reported elsewhere. During this analysis an HCV isolated from a patient was discovered that had large deletions in the 5 UTR. 57 of the HCV RNA found in this patient s sera had 113 or 116 bp deletions. Sequence data showed that domains IIIa to IIIc were missing. Previous studies have suggested that these domains may be important for translation. In vitro replicated HCV from this patient did not contain these .
