Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Replicative Homeostasis: A fundamental mechanism mediating selective viral replication and escape mutation | Virology Journal BioMed Central Hypothesis Open Access Replicative Homeostasis A fundamental mechanism mediating selective viral replication and escape mutation Richard Sallie Address Suite 35 95 Monash Avenue Nedlands Western Australia Australia Email Richard Sallie - sallier@ Corresponding author Published II February 2005 Virology Journal 2005 2 I0 doi 1743-422X-2-10 Received 23 January 2005 Accepted II February 2005 This article is available from http content 2 I I0 2005 Sallie licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Hepatitis C HCV hepatitis B HBV the human immunodeficiency viruses HIV and other viruses that replicate via RNA intermediaries cause an enormous burden of disease and premature death worldwide. These viruses circulate within infected hosts as vast populations of closely related but genetically diverse molecules known as quasispecies . The mechanism s by which this extreme genetic and antigenic diversity is stably maintained are unclear but are fundamental to understanding viral persistence and pathobiology. The persistence of HCV an RNA virus is especially problematic and HCV stability maintained despite rapid genomic mutation is highly paradoxical. This paper presents the hypothesis and evidence that viruses capable of persistent infection autoregulate replication and the likely mechanism mediating autoregulation - Replicative Homeostasis - is described. Replicative homeostasis causes formation of stable but highly reactive equilibria that drive quasispecies expansion and generates escape mutation. Replicative homeostasis explains both viral kinetics and the enigma of RNA quasispecies stability and provides a rational mechanistic basis for all observed .
