Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies | Virology Journal BioMed Central Review Open Access Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies Caren J Stark and CD Atreya Address Division of Viral Products Center for Biologics Evaluation and Research US Food and Drug Administration Bethesda MD 20892 USA Email Caren J Stark - starkc@ CD Atreya - atreya@ Corresponding author Published 15 April 2005 Received 13 April 2005 Accepted 15 April 2005 Virology Journal 2005 2 35 doi 186 1743-422X-2-35 This article is available from http content 2 1 35 2005 Stark and Atreya licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract In the aftermath of the SARS epidemic there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence identification of the viral receptor development of an infectious cDNA clone and the identification of viral antigens that elicit neutralizing antibodies. However there is still a large gap in our understanding of how SARS-CoV interacts with the host cell and the rapidly changing viral genome adds another variable to this equation. Now the SARS-CoV story has entered a new phase a search for preventive strategies and a cure for the disease. This review highlights the progress made in identifying molecular aspects of SARS-CoV biology that is relevant in developing disease prevention strategies. Authors conclude that development of successful SARS-CoV vaccines and antivirals depends on the progress we make in these areas in the immediate future. Introduction Following reports of the last case of the severe acute respiratory syndrome SARS epidemic in July 2003 there
