Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1 | Virology Journal BioMed Central Research Open Access Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1 William P Halford 1 Jennifer L Maender2 and Bryan M Gebhardt3 Address 1Dept of Veterinary Molecular Biology Montana State University Bozeman MT USA 2Dept of Dermatology Baylor College of Medicine Houston TX USA and 3Dept of Ophthalmology Louisiana State University Health Sciences Center New Orleans LA USA Email William P Halford - halford@ Jennifer L Maender - jmaender@ Bryan M Gebhardt - bgebha@ Corresponding author Published 17 July 2005 Received 05 May 2005 Virology Journal 2005 2 56 doi 1743-422X-2-56 Accepted I7 July 2005 This article is available from http content 2 1 56 2005 Halford et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Interferon-Y acts to multiply the potency with which innate interferons a p suppress herpes simplex virus type 1 HSV-1 replication. Recent evidence suggests that this interaction is functionally relevant in host defense against HSV- 1. However it is not clear which WBCs of the innate immune system if any limit HSV-1 spread in an IFN-Y dependent manner. The current study was initiated to determine if natural killer NK cells provide innate resistance to HSV-1 infection and if so to determine if this resistance is IFN-Y-dependent. Results Lymphocyte-deficient scid or rag2- - mice were used to test four predictions of the central hypothesis and thus determine if innate resistance to HSV-1 is dependent on 1. NK cell cytotoxicity 2. NK cells 3. WBCs or 4. the IFN-activated transcription factor Stat 1. Loss of NK cell cytotoxic function or depletion of NK cells .
