Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other "virus receptor" diseases | Virology Journal BioMed Central Hypothesis Open Access Replicative homeostasis II Influence of polymerase fidelity on RNA virus quasispecies biology Implications for immune recognition viral autoimmunity and other virus receptor diseases Richard Sallie Address Suite 35 95 Monash Avenue Nedlands Western Australia 6009 Australia Email Richard Sallie - sallier@ Corresponding author Published 22 August 2005 Virology Journal 2005 2 70 doi I86 I743-422X-2-70 Received 31 July 2005 Accepted 22 August 2005 This article is available from http content 2 1 70 2005 Sallie licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Much of the worlds population is in active or imminent danger from established infectious pathogens while sporadic and pandemic infections by these and emerging agents threaten everyone. RNA polymerases RNApol generate enormous genetic and consequent antigenic heterogeneity permitting both viruses and cellular pathogens to evade host defences. Thus RNApol causes more morbidity and premature mortality than any other molecule. The extraordinary genetic heterogeneity defining viral quasispecies results from RNApol infidelity causing rapid cumulative genomic RNA mutation a process that if uncontrolled would cause catastrophic loss of sequence integrity and inexorable quasispecies extinction. Selective replication and replicative homeostasis an epicyclical regulatory mechanism dynamically linking RNApol fidelity and processivity with quasispecies phenotypic diversity modulating polymerase fidelity and hence controlling quasispecies behaviour prevents this happening and also mediates immune escape. Perhaps more importantly ineluctable generation of broad phenotypic diversity after viral .
