Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Spectrum of musculo-skeletal disorders in sickle cell disease in Lagos, Nigeria | Balogun et al. Journal of Orthopaedic Surgery and Research 2010 5 2 http content 5 1 2 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH RESEARCH ARTICLE Open Access Spectrum of musculo-skeletal disorders in sickle cell disease in Lagos Nigeria Rufai A Balogun Dike C Obalum f Suleiman O Giwa Thomas O Adekoya-Cole Chidiebere N Ogo George O Enweluzo Abstract Background Sickle cell anemia SCA is a common genetic disease in Nigeria. Past studies from West Africa focused on isolated aspects of its medical and surgical presentations. To the best of our knowledge the musculoskeletal presentations amongst Nigerians with SCA have not been documented in a single all encompassing study. This work aims to prospectively document the musculo-skeletal disease burden among SCA patients. Methods In a prospective study of 318 consecutive patients with genotype-confirmed SCA at the Lagos University Teaching Hospital LUTH the musculo-skeletal pathologies anatomic sites grade of disease age at presentation and management outcome were recorded over a one-year period. Data obtained were analyzed using Epi-Info software version . Data are presented as frequencies and mean values SD as appropriate. Results The HbSS genotype occurred in 296 while 22 were HbSC. 100 patients with average presenting haemoglobin concentration of g 100 ml in the study group presented with 131 musculoskeletal pathologies in 118 anatomic sites. Osteomyelitis 31 31 and septic arthritis 19 19 were most commonly observed in children less than 10 years. Skin ulcers and avascular necrosis AVN occurred predominantly in the older age groups with frequencies of 13 and 26 respectively. 20 of diagnosed cases of AVN presented with radiological grade 4 disease. The lower limbs were involved in 84 of sites affected. Lesions involving the spine were rare 11 . Multiple presentations occurred in 89 of patients 62 of which were children below 10 years. .
