Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Biology and augmentation of tendon-bone insertion repair | Lui et al. Journal of Orthopaedic Surgery and Research 2010 5 59 http content 5 1 59 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH REVIEW Open Access Biology and augmentation of tendon-bone insertion repair Pauline Po-Yee Lui1 2 3 Peng Zhang4 Kai-Ming Chan1 2 Ling Qin1 4 Abstract Surgical reattachment of tendon and bone such as in rotator cuff repair patellar-patella tendon repair and anterior cruciate ligament ACL reconstruction often fails due to the failure of regeneration of the specialized tissue enthesis which connects tendon to bone. Tendon-to-bone healing taking place between inhomogenous tissues is a slow process compared to healing within homogenous tissue such as tendon to tendon or bone to bone healing. Therefore special attention must be paid to augment tendon to bone insertion TBI healing. Apart from surgical fixation biological and biophysical interventions have been studied aiming at regeneration of TBI healing complex especially the regeneration of interpositioned fibrocartilage and new bone at the healing junction. This paper described the biology and the factors influencing TBI healing using patella-patellar tendon PPT healing and tendon graft to bone tunnel healing in ACL reconstruction as examples. Recent development in the improvement of TBI healing and directions for future studies were also reviewed and discussed. 1. The Attachment of Tendon to Bone - TendonBone Insertion TBI The attachment of tendon to bone presents a great challenge in engineering because a soft compliant material tendon attaches to a stiff bone material 1 . A high level of stress is expected to accumulate at the interface due to the difference in stiffness of the two materials 2 . This problem is solved by the presence of a unique transitional tissue called enthesis at the interface which can effectively transfer the stress from tendon to bone and vice versa through its gradual change in structure composition and mechanical behavior. There are two types
