Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : The effect of muscle contusion on cortical bone and muscle perfusion following reamed, intramedullary nailing: a novel canine tibia fracture model | Koo et al. Journal of Orthopaedic Surgery and Research 2010 5 89 http content 5 1 89 ffmra JOURNAL OF ORTHOPAEDIC ajjtj SURGERY AND RESEARCH RESEARCH ARTICLE Open Access The effect of muscle contusion on cortical bone and muscle perfusion following reamed intramedullary nailing a novel canine tibia fracture model Henry Koo1 Thomas Hupel2 3 Rad Zdero3 4 Alexei Tov4 Emil H Schemitsch 4 5 Abstract Background Management of tibial fractures associated with soft tissue injury remains controversial. Previous studies have assessed perfusion of the fractured tibia and surrounding soft tissues in the setting of a normal soft tissue envelope. The purpose of this study was to determine the effects of muscle contusion on blood flow to the tibial cortex and muscle during reamed intramedullary nailing of a tibial fracture. Methods Eleven adult canines were distributed into two groups Contusion or No-Contusion. The left tibia of each canine underwent segmental osteotomy followed by limited reaming and locked intramedullary nailing. Six of the 11 canines had the anterior muscle compartment contused in a standardized fashion. Laser doppler flowmetry was used to measure cortical bone and muscle perfusion during the index procedure and at 11 weeks post-operatively. Results Following a standardized contusion muscle perfusion in the Contusion group was higher compared to the No-Contusion group at post-osteotomy and post-reaming p . Bone perfusion decreased to a larger extent in the Contusion group compared to the No-Contusion group following osteotomy p and the difference in bone perfusion between the two groups remained significant throughout the entire procedure p . At 11 weeks muscle perfusion was similar in both groups p . There was a sustained decrease in overall bone perfusion in the Contusion group at 11 weeks compared to the No-Contusion group p . Conclusions Injury to the soft tissue envelope may have some deleterious effects on .
