Tham khảo tài liệu 'báo cáo hóa học:" treatment of refractory hip pain with sodium hyaluronate (hyalgan©) in a patient with the marshall-smith syndrome: a case report"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Salter et al. Journal of Orthopaedic Surgery and Research 2010 5 61 http content 5 1 61 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH CASE REPORT Open Access Treatment of refractory hip pain with sodium hyaluronate Hyalgan in a patient with the Marshall-Smith Syndrome A case report Matthew Salter Chandoo Kalmat Henry Kroll David Kim Abstract The Marshall Smith Syndrome MSS is a rare congenital disorder displaying a constellation of unique symptoms including orofacial dysmorphisms accelerated osseous maturation and dysplasias mental retardation and respiratory maladies. Few individuals with MSS survive past early childhood. In this case report we describe a unique treatment for a 30 year-old patient with MSS who presented to our pain medicine clinic for management of pain secondary to uncontrolled bilateral hip dysplasias. Background The Marshall-Smith Syndrome was first described in 1971 by Marshall et al as a rare congenital disorder and to date there are fewer than 40 reported cases 1-3 . The etiology is unknown but is presumed to be due to a de novo dominant mutation. It is characterized by a constellation of features involving the neurologic and respiratory systems and accelerated skeletal maturation leading to skeletal dysplasias. Patients have retarded intellectual development small chins glossoptosis prominent eyes protruding foreheads and are small in stature. They generally do not survive past early childhood mainly due to respiratory complications such as aspiration pneumonia. However if the respiratory conditions are managed aggressively patients have been known to survive longer. To our knowledge our patient is one of the oldest living patients with this rare disorder 3 . Given the natural history of the syndrome one would anticipate that older subjects would suffer a great deal of pain as a result of the accelerated skeletal maturation. We report a unique treatment of incapacitating bilateral hip pain in a 30 year-old MSS patient with
