Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Non-invasive interactive neurostimulation (InterX™) reduces acute pain in patients following total knee replacement surgery: a randomised, controlled trial | Nigam et al. Journal of Orthopaedic Surgery and Research 2011 6 45 http content 6 1 45 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH RESEARCH ARTICLE Open Access Non-invasive interactive neurostimulation InterX reduces acute pain in patients following total knee replacement surgery a randomised controlled trial Ashok K Nigam1 Drena M Taylor1 and Zulia Valeyeva2 Abstract Background Adequate post-operative pain relief following total knee replacement TKR is very important to optimal post-operative recovery. Faster mobilisation and rehabilitation ultimately results in optimum recovery outcomes but pain is often the limiting factor. This study evaluates the potential clinical benefit of the InterX neurostimulation device on pain reduction and rehabilitative outcome. Methods A clinical trial under the Hywel Dda Clinical Audit Committee to validate the clinical benefit of Non-invasive Interactive Neurostimulation NIN therapy using the InterX device was performed in patients undergoing TKR. 61 patients were randomised to treatment groups in blocks of two from the Theatre Operation List. The control group received the standard hospital course of pain medication and rehabilitation twice daily for 3 post-op days. The experimental group received 8 sessions of NIN therapy over 3 post-op days in addition to the standard course received by the Control group. Pain and range of motion were collected as the primary study measu res. Results Sixty one subjects were enrolled and randomised but 2 subjects one group were excluded due to missing data at Baseline Final one subject in the InterX group was excluded due to pre-existing rheumatoid pain conditions confounding the analysis. The experimental group pre- to post-session Verbal Rating Scale for pain VRS showed that NIN therapy consistently reduced the pain scores by a mean of points SE . The NIN pre-treatment score at Final was used for the primary ANCOVA comparison demonstrating a significantly greater .
