Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Osseointegration of porous titanium implants with and without electrochemically deposited DCPD coating in an ovine model | Chen et al. Journal of Orthopaedic Surgery and Research 2011 6 56 http content 6 1 56 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH RESEARCH ARTICLE Open Access Osseointegration of porous titanium implants with and without electrochemically deposited DCPD coating in an ovine model Dong Chen 1 Nicky Bertollo1 Abe Lau1 Naoya Taki2 Tomofumi Nishino3 Hajime Mishima3 Haruo Kawamura4 and William R Walsh1 Abstract Background Uncemented fixation of components in joint arthroplasty is achieved primarily through de novo bone formation at the bone-implant interface and establishment of a biological and mechanical interlock. In order to enhance bone-implant integration osteoconductive coatings and the methods of application thereof are continuously being developed and applied to highly porous and roughened implant substrates. In this study the effects of an electrochemically-deposited dicalcium phosphate dihydrate DCPD coating of a porous substrate on implant osseointegration was assessed using a standard uncemented implant fixation model in sheep. Methods Plasma sprayed titanium implants with and without a DCPD coating were inserted into defects drilled into the cancellous and cortical sites of the femur and tibia. Cancellous implants were inserted in a press-fit scenario whilst cortical implants were inserted in a line-to-line fit. Specimens were retrieved at 1 2 4 8 and 12 weeks postoperatively. Interfacial shear-strength of the cortical sites was assessed using a push-out test whilst bone ingrowth ongrowth and remodelling were investigated using histologic and histomorphometric endpoints. Results DCPD coating significantly improved cancellous bone ingrowth at 4 weeks but had no significant effect on mechanical stability in cortical bone up to 12 weeks postoperatively. Whilst a significant reduction in cancellous bone ongrowth was observed from 4 to 12 weeks for the DCPD coating no other statistically significant differences in ongrowth or ingrowth in .
