Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep | Journal of Ovarian Research BioMed Central Research Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles in vitro and in vivo studies in cattle and sheep Kate E Ryan1 Claire Glister3 Pat Lonergan1 Finian Martin2 Phil G Knight3 and Alexander CO Evans 1 Address 1School of Agriculture Food Science and Veterinary Medicine Conway Institute College of Life Science University College Dublin Belfield Dublin 4 Ireland 2School of Biomolecular and Biomedical Science Conway Institute College of Life Science University College Dublin Belfield Dublin 4 Ireland and 3School of Biological Sciences University of Reading Whiteknights Reading RG6 6AJ UK Email Kate E Ryan - Claire Glister - Pat Lonergan - Finian Martin - Phil G Knight - Alexander CO Evans - Corresponding author Open Access Published I October 2008 Received 10 July 2008 Journal of Ovarian Research 2008 1 2 doi 1757-2215-1-2 Accepted 1 October 2008 This article is available from http content 1 1 2 2008 Ryan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background The intracellular signalling mechanisms that regulate ovarian follicle development are unclear however we have recently shown differences in the Akt and Erk signalling pathways in dominant compared to subordinate follicles. The aim of this study was to investigate the effects of inhibiting Akt and Erk phosphorylation on IGF- and gonadotropin- stimulated granulosa and theca cell function in vitro and on follicle development in .
