Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Ovarian cancer: emerging concept on cancer stem cells | Journal of Ovarian Research BioMed Central Open Access Ovarian cancer emerging concept on cancer stem cells Moorthy P Ponnusamy1 and Surinder K Batra 1 2 Address Department of Biochemistry and Molecular Biology University of Nebraska Medical Center Omaha NE 68198-5870 USA and 2Eppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical Center Omaha NE 68198-5870 USA Email Moorthy P Ponnusamy - mpalanim@ Surinder K Batra - sbatra@ Corresponding author Published 12 October 2008 Received 23 August 2008 Accepted 12 October 2008 Journal of Ovarian Research 2008 1 4 doi 1757-2215-1-4 This article is available from http content 1 1 4 2008 Ponnusamy and Batra licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Emerging evidence suggests that the capacity of a tumor to grow and propagate is dependent on a small subset of cells within a tumor termed cancer stem cells. In fact cancer cells like stem cells can proliferate indefinitely through a dysregulated cellular self-renewal capacity. Cancer stem cells may originate due to the distribution into self-renewal and differentiation pathways occurring in multi-potential stem cells tissue-specific stem cells progenitor cells and cancer cells. Recent studies have shown that ovarian cancer also contains stem cells or tumor-initiating cells. Moreover ovarian serous adenocarcinomas were disaggregated and subjected to growth conditions to select for self-renewing non-adherent spheroids previously shown to be derived from tissue stem cells. A recent study showed that epithelial ovarian cancer was derived from a sub population of CD44
