Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : BRCA1/2 genetic background-based therapeutic tailoring of human ovarian cancer: hope or reality? | Journal of Ovarian Research BioMed Central Open Access Review BRCA1 2 genetic background-based therapeutic tailoring of human ovarian cancer hope or reality Pierosandro Tagliaferri 1 2 Monica Ventura1 2 Francesco Baudi1 2 lole Cucinotto1 2 Mariamena Arbitrio1 2 Maria Teresa Di Martino1 2 and Pierfrancesco Tassone1 2 Address 1Medical Oncology Unit and Center for Genetic Counseling and Innovative Treatments Tommaso Campanella Cancer Center Catanzaro 88100 Italy and 2Magna Gracia University Campus Salvatore Venuta Catanzaro 88100 Italy Email Pierosandro Tagliaferri - tagliaferri@ Monica Ventura - monven@ Francesco Baudi - baudi@ lole Cucinotto - iolecucinotto@ Mariamena Arbitrio - Maria Teresa Di Martino - teresadm@ Pierfrancesco Tassone - tassone@ Corresponding author Published 13 October 2009 Received 31 July 2009 Accepted 13 October 2009 Journal of Ovarian Research 2009 2 14 doi 1757-2215-2-14 This article is available from http content 2 1 14 2009 Tagliaferri et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Ovarian epithelial tumors are an hallmark of hereditary cancer syndromes which are related to the germ-line inheritance of cancer predisposing mutations in BRCA1 and BRCA2 genes. Although these genes have been associated with multiple different physiologic functions they share an important role in DNA repair mechanisms and therefore in the whole genomic integrity control. These findings have risen a variety of issues in terms of treatment and prevention of breast and ovarian tumors arising in this context. Enhanced sensitivity .
