Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Mucins in ovarian cancer diagnosis and therapy | Journal of Ovarian Research BioMed Central Review Mucins in ovarian cancer diagnosis and therapy Subhash C Chauhan 1 2 Deepak Kumar3 and Meena Jaggi1 2 Open Access Address 1Cancer Biology Research Center Sanford Research USD Sioux Falls SD USA 2Department of OB GYN and Basic Biomedical Science Division Sanford School of Medicine Sioux Falls SD USA and 3Department of Biological and Environmental Sciences University of the District of Columbia Washington DC USA Email Subhash C Chauhan - Deepak Kumar - dkumar@ Meena Jaggi - Corresponding author Published 24 December 2009 Received 4 September 2009 Journal of Ovarian Research 2009 2 21 doi 1757-2215-2-21 Accepted 24 December 2009 This article is available from http content 2 1 21 2009 Chauhan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Ovarian cancer is the most lethal gynecologic malignancy and the five-year survival rate is only 35 after diagnosis. Epithelial ovarian cancer is a highly metastatic disease characterized by widespread peritoneal dissemination and ascites. The death incidences from ovarian cancer could be significantly lowered by developing new methods for the early diagnosis and treatment of this fatal disease. Several potential markers have been identified recently. However mucins are the most promising markers for ovarian cancer diagnosis. Mucins are large extracellular heavily glycosylated proteins and their aberrant expression has been implicated in the pathogenesis of a variety of cancers including ovarian cancer. This review will summarize known facts about the pathological and molecular characteristics of ovarian cancer the current status of ovarian cancer
