Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Serum and follicular anti-Mullerian hormone levels in women with polycystic ovary syndrome (PCOS) under metformin | Falbo et al. Journal of Ovarian Research 2010 3 16 http content 3 1 16 RESEARCH JOURNAL OF OVARIAN RESEARCH Open Access Serum and follicular anti-Mullerian hormone levels in women with polycystic ovary syndrome PCOS under metformin 1 1 1 2 2 1 3 Angela Falbo Morena Rocca Tiziana Russo Antonietta D Ettore Achille Tolino Fulvio Zullo Francesco Orio Stefano Palomba1 Abstract Background No data regarding metformin effects on follicular fluid anti-Mullerian hormone AMH levels were to date available in literature. The aim of the present study was to evaluate in patients with polycystic ovary syndrome PCOS whether metformin administration affects serum and follicular AMH levels and whether this is related to ovarian response to the treatment. Methods Twenty young patients with PCOS who had received metformin were enrolled. Ten patients were anovulatory Met-anov group whereas the other 10 were ovulatory Met-ov group but had failed to conceive. Further untreated PCOS PCOS controls n. 10 and healthy controls non-PCOS controls n. 10 who were scheduled for laparoscopic surgery were enrolled. In each subjects clinical and biochemical evaluations were performed. AMH concentrations in blood and antral follicular fluid were assayed. Results In both Met-anov and Met-ov groups and without difference between them serum androgens and AMH and indices of insulin resistance were significantly p improved after treatment. On the other hand significant differences p between the two groups were detected with respect to the same biochemical parameters in antral follicular fluid. In the Met-anov group no significant correlation was observed between AMH concentrations in the follicular fluid and variation in serum androgens AMH and insulin resistance indexes whereas in Met-ov group significant correlations were detected between AMH levels in the follicular fluid and variation in serum androgens AMH and insulin resistance indexes. Conclusions Metformin .
