Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : HOX genes in ovarian cancer | Kelly et al. Journal of Ovarian Research 2011 4 16 http content 4 1 16 JOURNAL OF OVARIAN RESEARCH REVIEW Open Access HOX genes in ovarian cancer 1 1 2 1 1 Zoe L Kelly Agnieszka Michael Simon Butler-Manuel Hardev S Pandha and Richard GL Morgan Abstract The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development. Here we review a number of recent studies showing that HOX genes are strongly expressed in ovarian cancer and that in some cases the expression of specific HOX genes is sufficient to confer a particular identity and phenotype upon cancer cells. We also review the recent advances in elucidating the different functions of HOX genes in ovarian cancer. A literature search was performed using the search terms HOX genes including specific HOX genes ovarian cancer and oncogenesis. Articles were accessed through searches performed in ISI Web of Knowledge PubMed and ScienceDirect. Taken together these studies have shown that HOX genes play a role in the oncogenesis of ovarian cancer and function in the inhibition of apoptosis DNA repair and enhanced cell motility. The function of HOX genes in ovarian cancer oncogenesis supports their potential role as prognostic and diagnostic markers and as therapeutic targets in this disease. Keywords Ovarian Cancer HOX Therapy HXR9 Introduction The HOX genes constitute a family of transcription factors that play key roles in embryonic development especially in the patterning of the anterior to posterior axis from the level of the hindbrain to the end of the spine. They are characterized by a highly conserved homeodo-main region consisting of a 61-amino acid motif which enables HOX proteins to bind to specific regions of DNA in order to transcriptionally activate or repress target genes. HOX proteins can function as monomers or homodimers although their target DNA binding affinities and specificities are enhanced by functioning as .
