Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Decreased levels of serum glutathione peroxidase 3 are associated with papillary serous ovarian cancer and disease progression | Agnani et al. Journal of Ovarian Research 2011 4 18 http content 4 1 18 RESEARCH JOURNAL OF OVARIAN RESEARCH Open Access Decreased levels of serum glutathione peroxidase 3 are associated with papillary serous ovarian cancer and disease progression P s A 1 1 12 2 3 Deep Agnani Olga Camacho-Vanegas Catalina Camacho Shashi Lele Kunle Odunsi Samantha Cohen Peter Dottino3 and John A Martignetti1 4 5 Abstract Background Glutathione peroxidase 3 GPX3 is a selenocysteine-containing antioxidant enzyme that reacts with hydrogen peroxide and soluble fatty acid hydroperoxides thereby helping to maintain redox balance within cells. Serum levels of GPX3 have been found to be reduced in various cancers including prostrate thyroid colorectal breast and gastric cancers. Intriguingly GPX3 has been reported to be upregulated in clear cell ovarian cancer tissues and thus may have implications in chemotherapeutic resistance. Since clear cell and serous subtypes of ovarian cancer represent two distinct disease entities the aim of this study was to determine GPX3 levels in serous ovarian cancer patients and establish its potential as a biomarker for detection and or surveillance of papillary serous ovarian cancer the most frequent form of ovarian tumors in women. Patients and Methods Serum was obtained from 66 patients median age 62 years range 22-89 prior to surgery and 65 controls with a comparable age-range median age 53 years range 25-83 . ELISA was used to determine the levels of serum GPX3. The Mann Whitney U test was performed to determine statistical significance between the levels of serum GPX3 in patients and controls. Results Serum levels of GPX3 were found to be significantly lower in patients than controls p 1 X 10-2 . Furthermore this was found to be dependent on the stage of disease. While levels in early stage I II patients showed no significant difference when compared to controls there was a significant reduction in late stage III IV p 9 X 10-4 .
