Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : The HIV-1 Non-subtype B Workgroup: An International Collaboration for the Collection and Analysis of HIV-1 Non-subtype B Data | Journal of the International AIDS Society BioMed Central Commentary The HIV-1 Non-subtype B Workgroup An International Collaboration for the Collection and Analysis of HIV-1 Non-subtype B Data Rami Kantor 1 Robert W Shafer2 David Katzenstein3 for the HIV-1 Nonsubtype B Workgroup Open Access Address Assistant Professor Research Division of Infectious Diseases Brown University Providence Rhode Island 2Assistant Professor Division of Infectious Diseases Stanford University Stanford California and 3Professor Division of Infectious Diseases Stanford University Stanford California Corresponding author Published 23 February 2005 Journal of the International AIDS Society 2005 7 71 This article is available from http content 7 l 7l HIV Diversity and Drug Resistance HIV-1 group M the major pathogen responsible for the AIDS pandemic is characterized by a wide range of genetic diversity among distinct subtypes A-K sub-subtypes A1 A2 F1 F2 and circulating recombinant forms CRF01_AE CRF02_AG and more . The different variants are approximately equidistantly related and are distinct from one another across the entire genome. 1 Current FDA-approved antiretroviral medications include 18 drugs targeted against 2 pol gene enzymes the reverse transcriptase RT and the protease. Antiretroviral drug resistance is common as treatment efforts intensify and is both a cause and a result of virologic treatment failure and incomplete virus suppression. Drug resistance is an adaptive viral response and once virologic failure occurs it is necessary to change drug therapy substituting to new drugs to which the virus is susceptible for suppression of virus replication. The larger body of experience with treatment of subtype B virus infection has provided considerable data on the patterns of resistance which may emerge following virologic failure. 2 The Global Paradox Most of our current knowledge of HIV-1 drug susceptibility and resistance and interpretations of genotypic changes
