Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Triple-Nucleoside Analog Antiretroviral Therapy: Is There Still a Role in Clinical Practice? A Review | Journal of the International AIDS Society BioMed Central Open Access Review article Triple-Nucleoside Analog Antiretroviral Therapy Is There Still a Role in Clinical Practice A Review Harold A Kessler Address Professor of Medicine and Immunology Microbiology Associate Director Section of Infectious Diseases Rush University Medical Center Chicago Illinois Email Harold A Kessler - hkessler@ Published 2 June 2005 Journal of the International AIDS Society 2005 7 70 This article is available from http content 7 2 70 Abstract__ The development and widespread clinical use of coformulated abacavir lamivudine zidovudine ABC 3TC ZDV as Trizivir represented an important advance in the management of HIV-infected patients especially those with adherence challenges. With a low pill burden no food restrictions limited drug-drug interactions and a favorable resistance profile ABC 3TC ZDV remains an alternative option in the US Department of Health and Human Services Consensus Panel Guidelines as initial treatment in antiretroviral-naive patients. Recent data have shown ABC 3TC ZDV to be less efficacious in suppressing and or maintaining suppression of virologic replication compared with efavirenz-containing antiretroviral therapy. Although triple-nucleoside nucleotide reverse transcriptase inhibitor t-NRTI combinations that do not contain a thymidine analog ZDV or stavudine have recently shown high virologic failure rates in clinical trials and clinical practice t-NRTI regimens containing a thymidine analog have consistently been shown to be efficacious. Introduction The development and widespread clinical use of coformulated abacavir lamivudine zidovudine ABC 3TC ZDV as Trizivir represented an important advance in the management of HIV-infected patients especially those with adherence challenges. With a low pill burden no food restrictions limited drug-drug interactions and a
