Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Sang Froid in a time of trouble: is a vaccine against HIV possible? | Journal of the International AIDS Society BioMed Central Open Access Sang Froid in a time of trouble is a vaccine against HIV possible Stanley A Plotkin 1 2 Address University of Pennsylvania Philadelphia PA USA and 2Sanofi Pasteur 4650 Wismer Road Doylestown PA 18902 USA Email Stanley A Plotkin - Published 2 February 2009 Received 25 November 2008 Journal of the International AIDS Society 2009 12 2 doi 1758-2652-12-2 Accepted 2 February 2009 This article is available from http content 12 1 2 2009 Plotkin licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Since the announcement of the STEP trial results in the past months we have heard many sober pronouncements on the possibility of an HIV vaccine. On the other hand optimistic quotations have been liberally used from Shakespeare s Henry Vs Once more unto the breach dear friends to Winston Churchill s definition of success as going from one failure to another with no loss of enthusiasm . I will forgo optimistic quotations for the phrase Sang Froid which translates literally from the French as cold blood what it really means is to avoid panic when things look bad to step back and coolly evaluate the situation. This is not to counsel easy optimism or to fly in face of the facts but I believe that while the situation is serious it is not desperate. I should stipulate at the outset that I am neither an immunologist nor an expert in HIV but someone who has spent his life in vaccine development. What I will try to do is to provide a point of view from that experience. There is no doubt that the results of STEP were disappointing not only did the vaccine fail to control viral load but may have adversely affected .
