Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Differences in resistance mutations among HIV-1 non-subtype B infections: a systematic review of evidence (1996–2008) | Journal of the International AIDS Society BioMed Central Open Access Review Differences in resistance mutations among HIV-1 non-subtype B infections a systematic review of evidence 1996-2008 Jorge L Martinez-Cajasf1 Nitika P Pait2 Marina B Klein2 and Mark A Wainberg 3 Address Department of Medicine Infectious Diseases Queen s University Kingston Ontario Canada 2McGill University Health Centre Montreal Quebec Canada and 3McGill University AIDS Centre Jewish General Hospital Montreal Quebec Canada Email Jorge L Martinez-Cajas - jm209@ Nitika P Pai - Marina B Klein - Mark AWainberg - Corresponding author fEqual contributors Published 30 June 2009 Received 30 November 2008 Journal of the International AIDS Society 2009 12 11 doi 1758-2652-12-11 Accepted 30 June 2009 This article is available from http content 12 1 11 2009 Martinez-Cajas et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Ninety percent of HIV-1-infected people worldwide harbour non-subtype B variants of HIV-1. Yet knowledge of resistance mutations in non-B HIV-1 and their clinical relevance is limited. Although a few reviews editorials and perspectives have been published alluding to this lack of data among non-B subtypes no systematic review has been performed to date. With this in mind we conducted a systematic review 1996-2008 of all published studies performed on the basis of non-subtype B HIV-1 infections treated with antiretroviral drugs that reported genotype resistance tests. Using an established search string 50 studies were deemed relevant for this review. These studies reported genotyping data from non-B HIV-1 infections that
