Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Impact of HIV-1 viral subtype on disease progression and response to antiretroviral therapy | Easterbrook et al. Journal of the International AIDS Society 2010 13 4 http content 13 1 4 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Impact of HIV-1 viral subtype on disease progression and response to antiretroviral therapy Philippa J Easterbrook1 Mel Smith2 Jane Mullen3 Siobhan O Shea3 Ian Chrystie3 Annemiek de Ruiter3 Iain D Tatt4 6 Anna Maria Geretti5 Mark Zuckerman2 Abstract Background Our intention was to compare the rate of immunological progression prior to antiretroviral therapy ART and the virological response to ART in patients infected with subtype B and four non-B HIV-1 subtypes A C D and the circulating recombinant form CRF02-AG in an ethnically diverse population of HIV-1-infected patients in south London. Methods A random sample of 861 HIV-1-infected patients attending HIV clinics at King s and St Thomas hospitals were subtyped using an in-house enzyme-linked immunoassay and env sequencing. Subtypes were compared on the rate of CD4 cell decline using a multi-level random effects model. Virological response to ART was compared using the time to virological suppression 400 copies ml and rate of virological rebound 400 copies ml following initial suppression. Results Complete subtype and epidemiological data were available for 679 patients of whom 357 were white and 230 were black African. Subtype B n 394 accounted for the majority of infections followed by subtypes C n 125 A n 84 D n 51 and CRF02-AG n 25 . There were no significant differences in rate of CD4 cell decline initial response to highly active antiretroviral therapy and subsequent rate of virological rebound for subtypes B A C and CRF02-AG. However a statistically significant four-fold faster rate of CD4 decline after adjustment for gender ethnicity and baseline CD4 count was observed for subtype D. In addition subtype D infections showed a higher rate of virological rebound at six months 70 compared with subtypes B 45 p A 35 p and
