Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : AIDS-associated Kaposi’s sarcoma is linked to advanced disease and high mortality in a primary care HIV programme in South Africa | Chu et al. Journal of the International AIDS Society 2010 13 23 http content 13 1 23 JOURNALOF THE INTERNATIONAL AIDS SOCIETY SHORT REPORT Open Access AIDS-associated Kaposi s sarcoma is linked to advanced disease and high mortality in a primary care HIV programme in South Africa 1 2 2 3 Kathryn M Chu Gcina Mahlangeni Sarah Swannet Nathan P Ford 1 Andrew Boulle Gilles Van Cutsem Abstract Background AIDS-associated Kaposi s sarcoma is an important life-threatening opportunistic infection among people living with HIV AIDS in resource-limited settings. In western countries the introduction of combination antiretroviral therapy cART and new chemotherapeutic agents has resulted in decreased incidence and improved prognosis of AIDS-associated Kaposi s sarcoma. In African cohorts however mortality remains high. In this study we describe disease characteristics and risk factors for mortality in a public sector HIV programme in South Africa. Methods We analysed data from an observational cohort study of HIV-infected adults with AIDS-associated Kaposi s sarcoma enrolled between May 2001 and January 2007 in three primary care clinics. Paper records from primary care and tertiary hospital oncology clinics were reviewed to determine the site of Kaposi s sarcoma lesions immune reconstitution inflammatory syndrome stage and treatment. Baseline characteristics cART use and survival outcomes were extracted from an electronic database maintained for routine monitoring and evaluation. Cox regression was used to model associations with mortality. Results Of 6292 patients 215 had AIDS-associated Kaposi s sarcoma. Lesions were most commonly oral 65 and on the lower extremities 56 . One quarter of patients did not receive cART. The mortality and lost-to-follow-up rates were respectively 25 95 CI 19-32 and eight 95 CI 5-13 per 100 person years for patients who received cART and 70 95 CI 42-117 and 119 80-176 per 100 person years for patients who did not .
