Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Baseline severe anaemia should not preclude use of zidovudine in antiretroviral-eligible patients in resource-limited settings | Kiragga et al. Journal of the International AIDS Society 2010 13 42 http content 13 1 42 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Baseline severe anaemia should not preclude use of zidovudine in antiretroviral-eligible patients in resource-limited settings Agnes N Kiragga1 Barbara Castelnuovo1 Damalie Nakanjako1 2 Yukari C Manabe1 3 Abstract Background Stavudine is no longer recommended as part of first-line therapy for patients initiating antiretroviral therapy ART in Uganda. Most patients are currently initiated on zidovudine-containing regimens which can induce anaemia. We investigated the risk factors for early severe anaemia in the first six months of ART initiation. Methods We defined baseline ART initiation anaemia as haemoglobin Hb g dL baseline severe anaemia as Hb 8 g dL and early severe anaemia as Hb 8 g dL within six months of ART initiation. Risk factors for the development of early severe anaemia were analyzed using a multivariable logistic regression model. Results In total 5494 patients initiated ART 821 15 had baseline anaemia and 296 5 had baseline severe anaemia. Early severe anaemia occurred in 109 4 of 3105 patients who had at least one Hb measurement in the first six months on ART. Patients with baseline anaemia had a larger increase in Hb median g dL IQR within the first six months compared with non-anaemic patients vs. p . Having a new tuberculosis episode OR 95 CI - MCV 80fL OR 95 CI and baseline severe anaemia OR 95 CI - were associated with early severe anaemia. Initiation on a zidovudine-based regimen was not associated with an increased risk of early severe anaemia. Conclusions Among patients in an urban HIV clinic in Uganda severe anaemia is modestly prevalent at ART initiation and improves with ART in the majority of patients. These data suggest that baseline severe anaemia should not be used as a criterion for .
