Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Trends in detectable viral load by calendar year in the Australian HIV observational database | JOURNALOF THE INTERNATIONAL AIDS SOCIETY Law et al. Journal of the International AIDS Society 2011 14 10 http content 14 1 10 RESEARCH Open Access Trends in detectable viral load by calendar year in the Australian HIV observational database l .itrhc .A I a 1 n Nlryry I lci 2 icl I Tdm rsldtrso 1 3 I Jocr PrAỳh4 l hci r hi Alt5 Rri Ai A I ilhsrll6 Potor f ano an7 Matthew G Law Ian Woolley David J Templeton Norm noth John cnudh Brian Mulhall reter Canavan Hamish McManus1 David A Cooper1 Kathy Petoumenos1 the Australian HIV Observational Database AHOD Abstract Background Recent papers have suggested that expanded combination antiretroviral treatment cART through lower viral load may be a strategy to reduce HIV transmission at a population level. We assessed calendar trends in detectable viral load in patients recruited to the Australian HIV Observational Database who were receiving cART. Methods Patients were included in analyses if they had started cART defined as three or more antiretrovirals and had at least one viral load assessment after 1 January 1997. We analyzed detectable viral load 400 copies ml in the first and second six months of each calendar year while receiving cART. Repeated measures logistic regression methods were used to account for within and between patient variability. Rates of detectable viral load were predicted allowing for patients lost to follow up. Results Analyses were based on 2439 patients and 31 339 viral load assessments between 1 January 1997 and 31 March 2009. Observed detectable viral load in patients receiving cART declined to in the first half of 2009. Predicted detectable viral load based on multivariate models allowing for patient loss to follow up also declined over time but at higher levels to in 2009. Conclusions Predicted detectable viral load in Australian HIV Observational Database patients receiving cART declined over calendar time albeit at higher levels than observed. However over this .
