Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Characteristics of non-AIDS-defining malignancies in the HAART era: a clinico-epidemiological study | JOURNALOF THE INTERNATIONAL AIDS SOCIETY Dauby et al. Journal of the International AIDS Society 2011 14 16 http content 14 1 16 RESEARCH Open Access Characteristics of non-AIDS-defining malignancies in the HAART era a clinico-epidemiological study Nicolas Dauby Stéphane De Wit Marc Delforge Valentina Coca Necsoi and Nathan Clumeck Abstract Background Non-AIDS-defining malignancies NADM are becoming a major cause of mortality in the era of highly active antiretroviral therapy. We wished to investigate the incidence risks factors and outcome of NADM in an urban cohort. Methods We carried out an observational cohort of HIV patients with 12 746 patient-years of follow up between January 2002 and March 2009. Socio-demographics and clinical characteristics of patients diagnosed with NADM were retrospectively compared with the rest of the cohort. Causes of death and risk factors associated with NADM were assessed using logistic regression. Survival analyses were performed with Kaplan-Meier estimates. Cancer incidences were compared with those of the general population of the Brussels-Capital Region using the standardized incidence ratio SIR . Results Forty-five NADM were diagnosed. At inclusion in the study patients with NADM were older than patients without NADM 47 years vs. 38 years p had a longer history of HIV infection 59 months vs. 39 months p a lower nadir CD4 count 110 cells mm3 vs. 224 cells mm3 p and a higher rate of previous AIDS events 33 vs. 20 p and of hepatitis C virus co-infection vs. 10 p . In multivariate analysis age over 45 at baseline OR 95 CI and a nadir CD4 count of less than 200 cells mm3 OR 95 CI were associated with NADM. NADM were independently associated with higher mortality in the cohort OR 95 CI . Women with cancer the majority of whom were of sub-Saharan African origin had poorer survival compared with men. The SIR for both sexes were .
