Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Towards targeted screening for acute HIV infections in British Columbia | JOURNALOF THE INTERNATIONAL AIDS SOCIETY Steinberg et al. Journal of the International AIDS Society 2011 14 39 http content 14 1 39 RESEARCH Open Access Towards targeted screening for acute HIV infections in British Columbia 1 13 1 1 1 Malcolm Steinberg Darrel A Cook Mark Gilbert Mel Krajden Devon Haag Peggy Tsang Elsie Wong James I Brooks4 5 Harriet Merks4 and Michael L Rekart1 3 Abstract Background Our objective was to describe the characteristics of acute and established HIV infections diagnosed in the Canadian province of British Columbia. Province-wide HIV testing and surveillance data were analyzed to inform recommendations for targeted use of screening algorithms to detect acute HIV infections. Methods Acute HIV infection was defined as a confirmed reactive HIV p24 antigen test or HIV nucleic acid test a non-reactive or reactive HIV EIA screening test and a non-reactive or indeterminate Western Blot. Characteristics of unique individuals were identified from the British Columbia HIV AIDS Surveillance System. Primary drug resistance and HIV subtypes were identified by analyzing HIV pol sequences from residual sera from newly infected individuals. Results From February 2006 to October 2008 61 individuals met the acute HIV infection case definition representing of the 987 newly diagnosed HIV infections during the analysis period. Acute HIV infection cases were more likely to be men who have sex with men crude OR 95 CI to have had a documented previous negative HIV test result crude OR 95 CI and to have reported a reason for testing due to suspected seroconversion symptoms crude OR 95 CI . HIV subtypes and rates of transmitted drug resistance across all classes of drugs were similar in persons with both acute and established HIV infections. Conclusions Targeted screening to detect acute HIV infection is a logical public health response to the HIV epidemic. Our findings suggest that acute
