Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : HIV and concurrent sexual partnerships: modelling the role of coital dilution | JOURNALOF THE INTERNATIONAL AIDS SOCIETY Sawers et al. Journal of the International AIDS Society 2011 14 44 http content 14 1 44 RESEARCH Open Access HIV and concurrent sexual partnerships modelling the role of coital dilution Larry Sawers1 Alan G Isaac1 and Eileen Stillwaggon2 Abstract Background The concurrency hypothesis asserts that high prevalence of overlapping sexual partnerships explains extraordinarily high HIV levels in sub-Saharan Africa. Earlier simulation models show that the network effect of concurrency can increase HIV incidence but those models do not account for the coital dilution effect nonprimary partnerships have lower coital frequency than primary partnerships . Methods We modify the model of Eaton et al AIDS and Behavior September 2010 to incorporate coital dilution by assigning lower coital frequencies to non-primary partnerships. We parameterize coital dilution based on the empirical work of Morris et al PLoS ONE December 2010 and others. Following Eaton et al we simulate the daily transmission of HIV over 250 years for 10 levels of concurrency. Results At every level of concurrency our focal coital-dilution simulation produces epidemic extinction. Our sensitivity analysis shows that this result is quite robust even modestly lower coital frequencies in non-primary partnerships lead to epidemic extinction. Conclusions In order to contribute usefully to the investigation of HIV prevalence simulation models of concurrent partnering and HIV epidemics must incorporate realistic degrees of coital dilution. Doing so dramatically reduces the role that concurrency can play in accelerating the spread of HIV and suggests that concurrency cannot be an important driver of HIV epidemics in sub-Saharan Africa. Alternative explanations for HIV epidemics in subSaharan Africa are needed. Background The concurrency hypothesis asserts that the high prevalence of overlapping sexual partnerships - known as concurrency or multiple concurrent .
