Polymer Thin Films Part 13

Tham khảo tài liệu 'polymer thin films part 13', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 17 Polymeric thin film technology for neural interfaces Review and perspectives Cristina Riggio Gianni Ciofani Vittoria Raffa Silvia Bossi Silvestro Micera and Alfred Cuschieri Scuola Superiore di Studi Universitari e Perfezionamento Sant Anna Pisa Italy 1. Introduction Thin polymeric film in nanomedicine An important and exciting direction of research in nanomedicine would be to gain a fundamental understanding of how living cells respond to nanostructures. At this aim thin film technology plays a key role in helping to understand the cell-surface interactions. Generally thin films are deposited onto bulk materials to achieve properties unattainable or not easily attainable in the substrate alone. In particularly in biomedicine polymeric thin films are used such as coating to improve the properties of biocompatibility thus avoiding typical inflammatory response of immunitary system especially when the system have to be permanently implanted Jeong et al. 1986 . Various biodegradable polymeric drug delivery devices have been developed for the sustained release of a variety of drugs which include micro and nanoparticles films foams wafers discs and micro- and nanofibers Jain 2000 Among them films have gained growing interest in various applications. Dorta et al. 2002 Jackson et al. 2002 Perugini et al. 2003 Dhanikula et al. 2004 Jackson et al. 2004 Grant et al. 2005 Alexis et al. 2005 Westedt et al. 2006 Heller et . For example films for stent applications have been devoleped to prevent early and late complications such as thrombotic closure and restenosis that have been reported with all current metallic stent devices. Westedt et al. 2006 Drachman et al. 2000 Alexis et al 2004 Hanefeld et al. 2006 . The surfaces of most metals are electropositively charged and therefore are thrombogenic because blood elements are negatively charged. So the drawbacks of metallic stents have encouraged significant efforts to explore other materials as possible stent matrices.

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