Health and Quality of Life Outcomes BioMed Central Research Open Access Development, validity and responsiveness of the Clinical COPD Questionnaire Thys van der Molen*1,5, Brigitte WM Willemse2, Siebrig Schokker1, Nick HT ten Hacken3, Dirkje S Postma3 and Elizabeth F Juniper4 Address: 1Department of General Practice, University of Groningen, Groningen, The Netherlands, 2Department of Pathology, University Hospital Groningen, Groningen, The Netherlands, 3Department of Pulmonary Diseases, University Hospital Groningen, Groningen, The Netherlands, 4Department of Clinical Epidemiology and Biostatisitics, Mc Master University of Health Sciences, Hamilton, Ontario, Canada and 5Department of General Practice and Primary Care, University of Aberdeen, Scotland, United Kingdom Email: Thys van der Molen* - ;. | BioMed Central Health and Quality of Life Outcomes Research Open Access Development validity and responsiveness of the Clinical COPD Questionnaire Thys van der Molen 1 5 Brigitte WM Willemse2 Siebrig Schokker1 Nick HT ten Hacken3 Dirkje S Postma3 and Elizabeth F Juniper4 Address Department of General Practice University of Groningen Groningen The Netherlands 2Department of Pathology University Hospital Groningen Groningen The Netherlands 3Department of Pulmonary Diseases University Hospital Groningen Groningen The Netherlands 4Department of Clinical Epidemiology and Biostatisitics Mc Master University of Health Sciences Hamilton Ontario Canada and 5Department of General Practice and Primary Care University of Aberdeen Scotland United Kingdom Email Thys van der Molen - Brigitte WM Willemse - Siebrig Schokker - Nick HT ten Hacken - Dirkje S Postma - Elizabeth F Juniper - juniper@ Corresponding author Published 28 April 2003 Received 27 February 2003 Accepted 28 April 2003 Health and Quality of Life Outcomes 2003 1 13 This article is available from http content 1 1 1 3 2003 van der Molen et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background The new Global Obstructive Lung Disease GOLD guidelines advice to focus treatment in Chronic Obstructive Pulmonary Disease COPD on improvement of functional state prevention of disease progression and minimization of symptoms. So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire CCQ . Methods Qualitative research with patients and clinicians .