Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Differential effect sizes of growth hormone replacement on quality of life, well-being and health status in growth hormone deficient patients: a meta-analysis | BioMed Central Health and Quality of Life Outcomes Research Open Access Differential effect sizes of growth hormone replacement on quality of life well-being and health status in growth hormone deficient patients a meta-analysis Jan Berend Deijen 1 Lucia I Arwert2 Joost Witlox1 and Madeleine L Drent2 Address Department of Clinical Neuropsychology Free University van der Boechorststraat 1 1081 BT Amsterdam the Netherlands and 2Department of Endocrinology VU University Medical Center PO Box 7057 1007 MB Amsterdam the Netherlands Email Jan Berend Deijen - Lucia I Arwert - Joost Witlox - Madeleine L Drent - Corresponding author Published 19 October 2005 Received 03 August 2005 Health and Quality ofLife Outcomes 2005 3 63 doi l477-7525-3-63 Accepted 19 October 2005 This article is available from http contenV3 1 63 2005 Deijen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Patients with growth hormone deficiency GHD frequently report to suffer from an impaired Quality of Life QoL and growth hormone GH substitution is found to improve this. However the same test may be used for measuring QoL well-being or health status in different studies. QoL has been defined as the subjective appraisal of one s current life based primarily on psychological function. The most important in the appraisal of well-being is mental function and concerning health status patients evaluate physical function as most important. To differentiate the effects of GH replacement on psychological variables in patients with GHD we carried out a number of meta-analyses classifying questionnaires into instruments measuring QoL psychological .
