Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : The OnyCOE-t™ questionnaire: responsiveness and clinical meaningfulness of a patient-reported outcomes questionnaire for toenail onychomycosis | BioMed Central Health and Quality of Life Outcomes Research The OnyCOE-t questionnaire responsiveness and clinical meaningfulness of a patient-reported outcomes questionnaire for toenail onychomycosis Lori P Potter1 Susan D Mathias1 Monika Raut2 Farid Kianifard3 and AmirTavakkol 3 Open Access Address Ovation Research Group San Francisco CA USA 2Ortho Biotech Clinical Affairs LLC Bridgewater NJ USA and 3Novartis Pharmaceuticals Corporation East Hanover NJ USA Email Lori P Potter - lori39@ Susan D Mathias - smathias@ Monika Raut - mraut@ Farid Kianifard - AmirTavakkol - Corresponding author Published 15 August 2006 Received 25 March 2006 Health and Quality of Life Outcomes 2006 4 50 doi 1477-7525-4-50 Accepted 15 August 2006 This article is available from http content 4 1 50 2006 Potter et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background This research was conducted to confirm the validity and reliability and to assess the responsiveness and clinical meaningfulness of the OnyCOE-t a questionnaire specifically designed to measure patient-reported outcomes PRO associated with toenail onychomycosis. Methods 504 patients with toenail onychomycosis randomized to receive 12 weeks of terbinafine 250 mg day with or without target toenail debridement in the IRON-CLAD trial completed the OnyCOE-t at baseline weeks 6 12 24 and 48. The OnyCOE-t is composed of 6 multi-item scales and 1 singleitem scale. These include a 7-item Toenail Symptom assessment which comprises both Symptom Frequency and Symptom Bothersomeness scales an 8-item Appearance Problems scale a 7-item Physical Activities Problems scale a .
