Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Assessment of self-injection experience in patients with rheumatoid arthritis: psychometric validation of the Self-Injection Assessment Questionnaire (SIAQ) | Keininger and Coteur Health and Quality of Life Outcomes 2011 9 2 http content 9 1 2 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Assessment of self-injection experience in patients with rheumatoid arthritis psychometric validation of the Self-Injection Assessment Questionnaire SIAQ Dorothy Keininger Geoffroy Coteur Abstract Background Subcutaneous self-injection of medication has benefits for the patient and healthcare system but there are barriers such as dexterity problems and injection anxiety that can prevent self-injection being used effectively. An accurate method of evaluating patients experiences with self-injection would enable assessment of their success in giving self-injections and the likelihood of them adhering to a self-injection regimen. The aim of this study was to develop a questionnaire to measure overall patient experience with subcutaneous self-injection the Self-Injection Assessment Questionnaire SIAQ and to investigate its psychometric properties. Methods The construct validity and reliability of the SIAQ were tested in patients with rheumatoid arthritis who volunteered to inject certolizumab pegol using a standard syringe during an open-label multinational extension trial of the long-term safety and efficacy of this drug. The SIAQ PRE module was self-completed before the first self-injection and the POST module was self-completed following each of three fortnightly self-injections. Results Ninety-seven patients completed the SIAQ. All items correlated well with their respective domains in confirmatory factor analysis. As predicted compared with other participants patients with very low scores less than 3 out of 10 in PRE causal domains Feelings about injections and Self-confidence were significantly less satisfied with their first self-injection as were patients with a very low score in any POST causal domain Selfconfidence Feelings about injections Injection-site reactions and Ease of use demonstrating known-groups
