Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Health-related quality of life in patients with severe COPD hospitalized for exacerbations - comparing EQ-5D, SF-12 and SGRQ | Menn et al. Health and Quality of Life Outcomes 2010 8 39 http content 8 1 39 I HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Heplth-related quality of life in patients with severe COPD hospitalized for exacerbations - comparing EQ-5D SF-12 and SGRQ Petra Menn 1 Norbert Weber2 and Rolf Holle1 Abstract Background The aim of this study was to measure HrQoL during acute exacerbations of COPD using generic and disease-specific instruments and to assess completeness proportion with best or worst health state sensitivity to change and discriminative ability for each instrument. Methods EQ-5D SF-12 and SGRQ were obtained from COPD patients with GOLD stage III and IV hospitalized for an acute exacerbation both at admission and discharge. To assess the instruments properties utility values were calculated for EQ-5D and SF-12 and a total score was derived from the SGRQ. Results Mean utilities ranged from SF-12 stage IV to EQ-5D stage III at admission and from SF-12 stage IV to EQ-5D stage III at discharge. Completeness was best for EQ-5D and SGRQ while no utility value for the SF-12 could be calculated for more than 30 . For SGRQ subscales the minimal score occurred in up to 11 at admission while full health was observed for the EQ-5D at discharge in 13 . Sensitivity to change was generally good whereas discrimination between COPD stages was low for the EQ-5D. Conclusions Acute exacerbations seriously impair health status and quality of life. The EQ-5D is generally suitable to measure HrQoL in exacerbations of severe COPD although the high proportion of patients reporting full health at discharge poses a problem. The main issue with the SF-12 is the high proportion of missing values in a self-assessed setting. Properties of the SGRQ were satisfactory. However since no utility values can be derived from this diseasespecific instrument it is not suitable for cost-utility analyses in health-economic evaluations. Background Chronic .
