Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài :The psychological burden of an initially unexplained illness: patients with sternocostoclavicular hyperostosis before and after delayed diagnosis | van der Kloot et al. Health and Quality of Life Outcomes 2010 8 97 http content 8 1 97 HEALTH AND QUALITY of life outcomes RESEARCH Open Access The psychological burden of an initially unexplained illness patients with sternocostoclavicular hyperostosis before and after delayed diagnosis 1 2 1 1 2 Willem A van der Kloot Neveen AT Hamdy Laurian CS Hafkemeijer Femke MC den Dulk Sadhna A Chotkan Arnold AP van Emmerik3 Ad A Kaptein4 Abstract Background Sternocostoclavicular hyperostosis SCCH is a rare debilitating chronic inflammatory disorder of the anterior chest wall due to a chronic sterile osteomyelitis of unknown origin. SCCH is largely underdiagnosed and often misdiagnosed. In individual cases it can remain unrecognized for years. The purpose of this study is twofold. Firstly to evaluate the psychological condition of SCCH patients both in the sometimes quite extended prediagnostic period between first manifestations and confirmed diagnosis of the disease and in the current situation. Secondly to investigate the relationships between the pre-diagnostic and the current psychological conditions of confirmed SCCH patients. Methods Structured interviews were held with 52 confirmed SCCH patients. Questionnaires were included to assess posttraumatic stress symptoms social support aspects of pain illness perceptions self-reported health status and quality of life. Results SCCH patients reported stronger posttraumatic stress symptoms more unfavorable illness perceptions lower health status and poorer quality of life than healthy individuals and patients with other diseases or traumatic experiences. Psychological distress in the pre-diagnostic period was associated with unfavorable conditions in the current situation. Conclusion SCCH is an illness with serious psychological consequences. Psychological monitoring of patients with unexplained complaints is recommended as long as a diagnosis has not been reached. Background Patients who suffer from rare .