Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài :Patient- and provider-related determinants of generic and specific health-related quality of life of patients with chronic systolic heart failure in primary care: a cross-sectional study | Peters-Klimm et al. Health and Quality of Life Outcomes 2010 8 98 http content 8 1 98 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Patient- and provider-related determinants of generic and specific health-related quality of life of patients with chronic systolic heart failure in primary care a cross-sectional study 1 2 1 1 3 Frank Peters-Klimm Cornelia U Kunz Gunter Laux Joachim Szecsenyi Thomas Muller-Tasch Abstract Background Identifying the determinants of health-related quality of life HRQOL in patients with systolic heart failure CHF is rare in primary care studies often lack a defined sample a comprehensive set of variables and clear HRQOL outcomes. Our aim was to explore the impact of such a set of variables on generic and disease-specific HRQOL. Methods In a cross-sectional study we evaluated data from 318 eligible patients. HRQOL measures used were the SF-36 Physical Mental Component Summary PCS MCS and four domains of the KCCQ Functional status Quality of life Self efficacy Social limitation . Potential determinants instruments included socio-demographical variables age sex socio-economic status SES clinical . NYHA class LVEF NT-proBNP levels multimorbidity CIRS-G depression PHQ-9 behavioural EHFScBs and prescribing and provider . list size of and number. of GPs in practice variables. We performed linear mixed regression modelling accounting for clustering. Results Patients were predominantly male had a mean age of SD years had major depression according to PHQ-9. Across the final regression models eleven determinants explained 27 to 55 of variance frequency across models lowest highest b Depression 6x age 4x multimorbidity 4x list size 2x SES 2x and each of the following once no. of GPs per practice NYHA class COPD history of CABG surgery aldosterone antagonist medication and Self-care . Conclusions HRQOL was determined by a variety of .
