Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài :Barriers towards insulin therapy in type 2 diabetic patients: results of an observational longitudinal study | Hermanns et al. Health and Quality of Life Outcomes 2010 8 113 http content 8 1 113 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Barriers towards insulin therapy in type 2 diabetic patients results of an observational longitudinal study 1 f 1 f 1 f 2f 1 f Norbert Hermanns Marina Mahr Bernd Kulzer Soren E Skovlund Thomas Haak 1 Abstract Background The course of barriers towards insulin therapy was analysed in three different groups of type 2 diabetic patients. This observational longitudinal study surveyed a three-month follow-up. Methods Participants in this study totalled 130 type 2 diabetic patients. The first subgroup was on insulin therapy at baseline group 1 n 57 age yrs disease duration yrs HbA1c and remained on insulin at follow-up. Of an initial 73 insulin-naive patients 44 were switched to insulin therapy group 2 age yrs disease duration yrs HbA1c and 29 patients remained on an oral regimen group 3 age yrs disease duration yrs HbA1c . Barriers towards insulin therapy were measured using the Insulin Treatment Appraisal Scale ITAS . As generic instruments of health related quality of life patients completed also the Problem Areas of Diabetes Questionnaire PAID the WHO-5 Well-Being Scale WHO-5 the Centre for Epidemiologic Studies Depression Scale CES-D and the Trait Version of the State Trait Anxiety Inventory STAI at baseline and at three-month follow-up. Results At the three-month follow-up HbA1c had improved in all three groups vs. vs. . The course of negative appraisal of insulin therapy was significantly different in the three groups p .003 the ITAS score increased in patients remained on oral antidiabetic drugs to whereas it decreased in patients switched to insulin therapy to or remained on insulin treatment to . Diabetes-related distress trait anxiety and well-being showed
