Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Mass spectrometry based on a coupled Cooperpair box and nanomechanical resonator system | Jiang et al. Nanoscale Research Letters 2011 6 570 http content 6 1 570 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Mass spectrometry based on a coupled Cooperpair box and nanomechanical resonator system Cheng Jiang Bin Chen Jin-Jin Li and Ka-Di Zhu Abstract Nanomechanical resonators NRs with very high frequency have a great potential for mass sensing with unprecedented sensitivity. In this study we propose a scheme for mass sensing based on the NR capacitively coupled to a Cooper-pair box CPB driven by two microwave currents. The accreted mass landing on the resonator can be measured conveniently by tracking the resonance frequency shifts because of mass changes in the signal absorption spectrum. We demonstrate that frequency shifts induced by adsorption often 1587 bp DNA molecules can be well resolved in the absorption spectrum. Integration with the CPB enables capacitive readout of the mechanical resonance directly on the chip. 1 Introduction Nanoelectromechanical systems NEMS offer new prospects for a variety of important applications ranging from semiconductor-based technology to fundamental science 1 . In particular the minuscule masses of NEMS resonators combined with their high frequencies and high resonance quality factors are very appealing for mass sensing 2-7 . These NEMS-based mass sensing employs tracking the resonance frequency shifts of the resonators due to mass changes. The most frequently used techniques for measuring the resonance frequency are based on optical detection 8 . Though inherently simple and highly sensitive this technique is susceptible to temperature fluctuation noise because it usually generates heat and heat conduction. On the other hand it has experimentally been demonstrated that capacitive detection is less affected to noise than optical detection in ambient atmosphere 9 . Capacitive detection is realized by connecting NEMS resonator with standard microelectronics such
