Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Sleep quality in mechanically ventilated patients: comparison between NAVA and PSV modes | Delisle et al. Annals of Intensive Care 2011 1 42 http content 1 1 42 Ù Annals of Intensive Care a SpringerOpen Journal RESEARCH Open Access Sleep quality in mechanically ventilated patients comparison between NAVA and PSV modes Stéphane Delisle1 2 3 Paul Ouellet3 4 5 Patrick Bellemare 1 Jean-Pierre Tétrault3 and Pierre Arsenault3 Abstract Background Mechanical ventilation seems to occupy a major source in alteration in the quality and quantity of sleep among patients in intensive care. Quality of sleep is negatively affected with frequent patient-ventilator asynchronies and more specifically with modes of ventilation. The quality of sleep among ventilated patients seems to be related in part to the alteration between the capacities of the ventilator to meet patient demand. The objective of this study was to compare the impact of two modes of ventilation and patient-ventilator interaction on sleep architecture. Methods Prospective comparative crossover study in 14 conscious nonsedated mechanically ventilated adults during weaning in a university hospital medical intensive care unit. Patients were successively ventilated in a random ordered cross-over sequence with neurally adjusted ventilatory assist NAVA and pressure support ventilation PSV . Sleep polysomnography was performed during four 4-hour periods two with each mode in random order. Results The tracings of the flow airway pressure and electrical activity of the diaphragm were used to diagnose central apneas and ineffective efforts. The main abnormalities were a low percentage of rapid eye movement REM sleep for a median 25th-75th percentiles of range 8-20 of total sleep and a highly fragmented sleep with 25 arousals and awakenings per hour of sleep. Proportions of REM sleep duration were different in the two ventilatory modes range 3-11 in PSV and range 13-29 during NAVA p as well as the fragmentation index with 40 20 arousals and awakenings per hour in PSV
