Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Effects of paraoxonase activity and gene polymorphism on coronary vasomotion | Dunet et al. EJNMMI Research 2011 1 27 http content 1 1 27 9 EJNMMI Research a SpringerOpen Journal ORIGINAL RESEARCH Open Access Effects of paraoxonase activity and gene polymorphism on coronary vasomotion 12 12 3 1 Vincent Dunet Juan Ruiz Gilles Allenbach Paola Izzo Richard W James and John O Prior Abstract Background Paraoxonase 1 PON1 is recognized as a protective enzyme against LDL oxidation and PON1 polymorphism has been described as a factor influencing coronary heart disease CHD free survival. As coronary vasoreactivity is a surrogate of future cardiovascular events we aimed at assessing the respective effect of the PON1 genotype and activity on coronary vasoreactivity in a population of type 2 diabetic patients. Methods Nineteen patients with type 2 diabetes mellitus underwent 82Rb cardiac PET CT to quantify myocardial blood flow MBF at rest during cold pressor testing CPT and during adenosine-induced hyperaemia to compute myocardial flow reserve MFR . They were allocated according to Q192R and L55M polymorphisms into three groups wild-type and LM QR heterozygotes MM homozygotes and RR homozygotes and underwent a measurement of plasmatic PON1 activity. Relations between rest-MBF stress-MBF MFR and MBF response to CPT and PON1 genotypes and PON1 activity were assessed using Spearman s correlation and multivariate linear regression analysis. Results Although PON1 activity was significantly associated with PON1 polymorphism p there was no significant relation between the PON1 genotypes and the rest-MBF stress-MBF or MBF response to CPT p . The PON1 activity significantly correlated with the HDL plasma level p p age p p and MFR p p . Moreover on multivariate analysis PON1 activity was independently associated with MFR p . Conclusion Our study supports an independent association between PON1 activity and MFR. Whether PON1 contributes to promote coronary vasoreactivity through its antioxidant
