Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: ECOSM-a new joint project for assessing environmental risks of poorly soluble compounds used in cosmetics-project presentation | Damme et al. Environmental Sciences Europe 2011 23 30 http content 23 1 30 o Environmental Sciences Europe a SpringerOpen Journal RESEARCH Open Access ECOSM-a new joint project for assessing environmental risks of poorly soluble compounds used in cosmetics-project presentation 1 1 1 A z- 2 2 3 Stefanie KE Damme Hans-Toni Ratte Henner Hollert Anja Coors Thomas Knacker Klaus Rettinger Christoph Schulte4 and Andreas Schaffer1 Abstract Personal Care Products contain a multitude of substances which introduce certain functions to the product and show a great variability in physicochemical properties. Poorly soluble substances characterised by a low water solubility 1 mg l may constitute a substantial proportion of these products. Their production volume causes the need for aquatic risk assessment as requested . by the European Regulation on Registration Evaluation Authorisation and Restriction of Chemicals. As it is difficult to conduct toxicity tests at the threshold of the substance s water solubility a high lipophilicity complicates the performance of standardised ecotoxicological tests. For these substances standard tests mostly provide insufficient results and are often not suitable to assess the risk appropriately. One promising approach to address this problem is the poorly solubles approach . It assumes that highly lipophilic and poorly soluble substances have a low water concentration and consequently might cause low exposure to aquatic organisms. However as these substances may bioaccumulate high internal exposure might be reached leading to long-term effects. The poorly solubles approach defines an ecotoxicological threshold of no concern . According to the theory below this concentration neither acute nor long-term adverse effects on aquatic organisms are expected to occur. This threshold is derived from a comprehensive compilation of experimental data for inert substances with a narcotic mode of action and therefore currently restricted
