Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Nanoliposomes for encapsulation and delivery of the potential antitumoral methyl 6-methoxy-3-(4methoxyphenyl)-1H-indole-2-carboxylate | Abreu et al. Nanoscale Research Letters 2011 6 482 http content 6 1 482 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Nanoliposomes for encapsulation and delivery of the potential antitumoral methyl 6-methoxy-3- 4-methoxyphenyl -1H-indole-2-carboxylate 1 2 2 3 Ana S Abreu 1 Elisabete MS Castanheira Maria-João RP Queiroz Paula MT Ferreira Luis A Vale-Silva and Eugénia Pinto3 Abstract A potential antitumoral fluorescent indole derivative methyl 6-methoxy-3- 4-methoxyphenyl -1H-indole-2-carboxylate was evaluated for the in vitro cell growth inhibition on three human tumor cell lines MCF-7 breast adenocarcinoma A375-C5 melanoma and NCI-H460 non-small cell lung cancer after a continuous exposure of 48 h exhibiting very low GI50 values for all the cell lines tested to pM . This compound was encapsulated in different nanosized liposome formulations containing egg lecithin Egg-PC dipalmitoyl phosphatidylcholine DPPC dipalmitoyl phosphatidylglycerol DPPG DSPC cholesterol dihexadecyl phosphate and DSPE-PEG. Dynamic light scattering measurements showed that nanoliposomes with the encapsulated compound are generally monodisperse and with hydrodynamic diameters lower than 120 nm good stability and zeta potential values lower than -18 mV. Dialysis experiments allowed to monitor compound diffusion through the lipid membrane from DPPC DPPG donor liposomes to NBD-labelled lipid DPPC DPPG acceptor liposomes. Introduction Anticancer drugs are crucial agents in the global approach to fight cancer. Drug-loaded nanoparticles provide a perfect solution to afford higher therapeutic efficacy and or reducing toxicity and the possibility of targeting cancer tissues. Nanoliposomes are one of the best drug delivery systems for low molecular weight drugs imaging agents peptides proteins and nucleic acids. Nanoliposomes are able to enhance the performance of bioactive agents by improving their bioavailability in vitro and in .
