Tham khảo tài liệu 'biomedical engineering trends in materials science part 15', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 412 Biomedical Engineering Trends in Materials Science Therapeutic Agent Targeting Agent Genetic Material Polymer or Inorganic Coating Magnetic Core Tissue Permeation Agent Fluorophore Polyelectrolyte . coating l nlc Slllca fluorophore coating Heterodimmer Embedded ln a matrix Luminomagnetic Slllca-doped decorated nanoparticles LMNP Slllca polymerlc matrix Luminescent Quantum dot Magnetic nano particle Fluorophore QD core Covalent llnkage Labeled llposome coated Fluorophore é J shell Polymer stablllzed Fig. 3. left Targeting therapeutic luminescent and biocompatibility agents on the same NP surface enabling multifunctionality in a single MFMNP right adapted from Corr et al. 2008 Many different types of LMNPs according to their preparation route. To perform such nanoscale engineering bioconjugation chemistries and techniques utilized for protein coupling have been studied Sun et al. 2008 . Techniques such as avidin-biotin binding use of heterobifunctional linkers to form amide ester or disulfide bonds and more recently click chemistries Nandivada et al. 2007 have all been shown to be useful in attaching functional ligands to MNPs. In addition to understanding the mechanisms of these reactions those utilizing these techniques on MNPs may also find it useful to review basic concepts of colloidal science to avoid unwanted NP flocculation or aggregation Hunter 2001 . One example of adding functionality to MNPs has been the combination of organic dyes or fluorophores as optical agents allowing detection by multiple imaging modalities. Both magnetic and fluorescent inorganic NPs have been shown to play a significant role in nanotechnology. Just looking at the wealth of possible applications open to magnetic and fluorescent materials it is not hard to see why the combination of these two entities opens up the opportunity to provide new nanocomposites which could act as multi-targeting multi-functional and multi-treating tools. It is expected that the combination of
