Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: White fat, factitious hyperglycemia, and the role of FDG PET to enhance understanding of adipocyte metabolism | Hofman and Hicks EJNMMI Research 2011 1 2 http content 1 1 2 9 EJNMMI Research a SpringerOpen Journal CASE REPORT Open Access White fat factitious hyperglycemia and the role of FDG PET to enhance understanding of adipocyte metabolism Michael S Hofman1 2 and Rodney J Hicks1 2 Abstract The development of a hybrid PET CT led to the recognition of the enhanced glycolysis in brown fat. We report a previously unrecognized mechanism for altered fluorodeoxyglucose FDG biodistribution with diffuse white adipose tissue uptake. This occurred during a restaging scan for cervical cancer following administration of insulin in the setting of measured hyperglycemia. The patient s blood sugar normalized but she experienced symptoms and signs of hypoglycemia. A subsequent history indicated that the patient received intravenous high-dose vitamin C just prior to arrival. Ascorbic acid is a strong reducing agent and can cause erroneous false positive portable glucometer readings. Accordingly it is likely the patient was euglycemic on arrival and was administered FDG during a period of insulin-induced hypoglycemia. Prominent diffuse white adipose tissue gastric mucosal myocardial and very low hepatic and muscle activity were observed. The case provides insight into the metabolic changes that occur during hypoglycemia and the potential danger of relying on portable glucometer readings. We discuss the potential biological basis of this finding and provide recommendations on the avoidance of this complication. Background The development of hybrid positron emission tomogra-phy computed tomography PET CT devices led to the recognition of enhanced glycolysis in brown fat typically in the neck and paravertebral regions of the thorax and upper abdomen as a thermoregulatory response and under catecholamine stimulation 1-3 . Other atypical patterns of fat uptake in patients with lipodystrophy have been reported 2 3 We report a previously unrecognized mechanism for altered .
