Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial | Ware et al. Annals of Intensive Care 2011 1 20 http content 1 1 20 Ù Annals of Intensive Care a SpringerOpen Journal RESEARCH Open Access Advancing donor management research design and implementation of a large randomized placebo-controlled trial I r M r Ì I zs o A s vr i 1 I I I I Ỉ s rn 2 PA o I I I f I m f V3 A A ZS -Z I s f r I 4 c I I 7-s Ir I L .4 c u . Z-J u-Dmz l z5 6 7 Lorraine B ware laisuKi Koyama Dean Billheimer Megan LanoecK Elizabeth Johnson sandra Brady Gordon R Bernard1 Michael A Matthay5 6 7 and for the California Transplant Donor Network Abstract Background Given the persistent shortage of organs for transplantation new donor management strategies to improve both organ utilization and quality of procured organs are needed. Current management protocols for the care of the deceased donor before organ procurement are based on physiological rationale experiential reasoning and retrospective studies without rigorous testing. Although many factors contribute to the lacK of controlled clinical trials in donor management a major factor is the unique challenges posed by research in the brain-dead organ donor. Methods and Results This article describes the study design and the challenges faced during implementation of the Beta-agonists for Oxygenation in Lung Donors BOLD study a randomized placebo-controlled clinical trial of nebulized albuterol vs. placebo in 500 organ donors. The study design and implementation are described with emphasis on aspects of the study that are unique to research in brain-dead organ donors. Conclusions Experience gained during the design and implementation of the BOLD study should be useful for investigators planning future clinical trials in the brain-dead donor population and for intensivists who are involved in the care of the brain-dead organ donor. Introduction Despite recent efforts to improve donation awareness family consent clinical management and organ utilization there remains a .
